کنفرانس مهندسی برق ایران

صفحه اصلی / سی امین کنفرانس بین المللی مهندسی برق

Network-based functional connectivity in MDD with suicide ideation before and after TMS: An fMRI case study

نویسندگان :

Moslem Khafi¹ Morteza Fattahi² Hamid Soltanian-Zadeh³ Reza Rostami⁴

1- University of Tehran 2- University of Tehran 3- University of Tehran 4- University of Tehran

کلمات کلیدی :

Functional connectivity،independent component analysis،major depressive disorder،suicide ideation،transcranial magnetic stimulation

چکیده :

Brain Major depressive disorder (MDD) is a major psychological disorder worldwide. Suicide ideation is one of the most serious side effects of MDD. Suicide attempt in normal people is about 15 individuals in 100,000 but in people with MDD, this reaches 15 persons in 100. In this study, we investigated the effects of the transcranial magnetic stimulation (TMS) on network-based whole-brain connectivity in an MDD patient with suicide ideation. We implemented a combination of weight-adjusted second order blind identification (WASOBI) and efficient fast independent component analysis (EFICA) algorithms, called COMBI, as a promising method for identifying independent components in the resting-state fMRI data (rsfMRI) of a female subject. We performed group information guided independent component analysis (GIG-ICA) as a back-reconstruction step and then extracted the functional connectivity (FC). The results showed significant changes in specific brain networks. Functional connectivity increased between the following networks: sensorimotor and language; left executive control network (ECN) and language; dorsal DMN and auditory; dorsal default mode network (DMN); and basal ganglia showed increased connectivity after TMS. Besides, ventral DMN and language network illustrated decreased connectivity.