کنفرانس مهندسی برق ایران

صفحه اصلی / سی و چهارمین کنفرانس بین المللی مهندسی برق

Spatial Focusing of Temporal Interference Deep Brain Stimulation via Phase Modulation

نویسندگان :

Hassan Keshtkar¹ Mahdi Moltamesi² Hoda Ameri³ Amideddin Mataji-Kojouri⁴ Reza Faraji-Dana⁵

1- دانشگاه تهران، دانشکده مهندسی برق و کامپیوتر 2- دانشگاه تهران، دانشکده مهندسی برق و کامپیوتر 3- دانشگاه تهران، دانشکده مهندسی برق و کامپیوتر 4- دانشگاه تهران، دانشکده مهندسی برق و کامپیوتر 5- دانشگاه تهران، دانشکده مهندسی برق و کامپیوتر

کلمات کلیدی :

Deep Brain Stimulation،Temporal Interference،Phase Modulation،Spatial Focality،Neuroengineering

چکیده :

Noninvasive Deep Brain Stimulation (DBS) via Temporally Interfering (TI) electric fields has emerged as a promising method to stimulate deep neural targets without affecting superficial layers. However, the TI method, which relies on the interference of two high-frequency sinusoids with a small frequency difference, often suffers from a broad activation volume, potentially leading to off-target effects. In this paper, we propose a Phase-Modulated TI (PM-TI) strategy to enhance the spatial focality of the stimulation hotspot. By introducing a parametric modulation factor into the phase term of the carrier signals, we synthesized non-sinusoidal envelopes that concentrate the constructive interference in a narrower region. Simulation results demonstrate that increasing the modulation parameter significantly sharpens the electric field envelope profile, reducing the spread of activation compared to the conventional methods. This approach offers a software-defined solution to improve the precision of noninvasive deep brain stimulation.