کنفرانس مهندسی برق ایران

صفحه اصلی / سی و سومین کنفرانس بین المللی مهندسی برق

Design and fabrication tip tapered fiber optic dopamine sensor based on LSPR

نویسندگان :

Roksana Esmaeilpour¹ Mohammad Ismail zibaii² Masoumeh Barkand³ Marzieh Pajouhandeh⁴ Soroush Rostami⁵ Mehdi Banihashemi⁶ Mohammad-Mahdi Babakhani-fard⁷

1- دانشگاه آزاد تهران مرکز 2- دانشگاه شهید بهشتی 3- دانشگاه شهید بهشتی 4- دانشگاه شهید بهشتی 5- دانشگاه شهید بهشتی 6- دانشگاه تهران مرکز 7- دانشگاه شهید بهشتی

کلمات کلیدی :

Dopamine،Evanescent field،Fiber optic sensor،Gold nanoparticle،Refractive index،Surface plasmon

چکیده :

Dopamine (DA) plays an essential role in the central nervous system, influencing movement, emotion, and cognition. Disruptions in dopamine signaling can lead to conditions such as Parkinson's disease, schizophrenia, and depression. In this study a tip tapered fiber optic sensor based on local surface plasmon (LSPR) for measuring dopamine concentration using a specific DNA aptamer as a bioreceptors was presented. The tapered fiber was fabricated based on chemical etching and gold nanoparticles (AuNPs) were used to exciting the LSPR. Changing the surrounding refractive index (RI) leads changing the LSPR wavelength. The RI sensitivity sensor in range 1.333 RIU to 1.362 RIU was obtained 1296.60 nm/RIU. The sensitivity sensor to DA detection in range 1 fM to 0.1µM was measured and limit of detection sensor was obtained 100 pM.